A double-blind, placebo-controlled study enrolled patients who had extended histories of receiving and tolerating BOTOX injections, with prior individualized adjustment of dose. The mean BOTOX dose administered to patients in this study was 236 Units (25th to 75th percentile range of 198 Units to 300 Units). The BOTOX dose was divided among the affected muscles [see Clinical Studies (14.7)]. Dosing in initial and sequential treatment sessions should be tailored to the individual patient based on the patient’s head and neck position, localization of pain, muscle hypertrophy, patient response, and adverse event history. The initial dose for a patient without prior use of BOTOX should be at a lower dose, with subsequent dosing adjusted based on individual response.
Botox is used in adults to prevent chronic migraine headaches or migraine attacks that occur on 15 or more days per month and that last for at least 4 hours.
Autonomic dysreflexia associated with intradetrusor injections of BOTOX could occur in patients treated for detrusor overactivity associated with a neurologic condition and may require prompt medical therapy.
BOTOX is intended for injection into extraocular muscles utilizing the electrical activity recorded from the tip of the injection needle as a guide to placement within the target muscle.
OnabotulinumtoxinA injections should be given only by a trained medical professional, even when used for cosmetic purposes.
Patients should discontinue anti-platelet therapy at least 3 days before the injection procedure. Patients on anti-coagulant therapy need to be managed appropriately to decrease the risk of bleeding. Appropriate caution should be exercised when performing a cystoscopy.
An intravesical instillation of diluted local anesthetic with or without sedation may be used prior to injection, per local sitio practice. If a local anesthetic instillation is performed, the bladder should be drained and irrigated with sterile saline before injection.
The duration of post-injection catheterization for those who developed urinary retention is also shown.
Botox is injected into 7 specific muscle areas around your head and neck to help prevent migraine headaches or migraine attacks before they start.
There are pelo data on the presence of Botox in human milk or adverse effects on the botox developing infant. Consider the benefits of Botox versus the risks, and advise against breastfeeding unless the risk is justified.
The cosmetic benefits of this procedure were discovered by accident – the original reason Botox was injected into the masseter muscle was to relieve teeth grinding (also called bruxism) and jaw pain or tension. Continue reading
Reconstituted BOTOX should be clear, colorless, and free of particulate matter. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration and whenever the solution and the container permit.
Facial Anatomy: Everyone's facial structure and muscle placement are unique. A skilled injector assesses your specific anatomy to determine the optimal placement and dosage for your individual needs.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.